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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TP53BP1
All Species:
13.94
Human Site:
S452
Identified Species:
51.11
UniProt:
Q12888
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12888
NP_001135451.1
1972
213574
S452
P
G
S
L
P
I
P
S
Q
P
Q
F
S
H
D
Chimpanzee
Pan troglodytes
XP_001158270
1972
213535
S452
P
G
S
L
P
I
P
S
Q
P
Q
F
S
H
D
Rhesus Macaque
Macaca mulatta
XP_001107220
1972
213653
S452
S
G
S
L
P
I
P
S
Q
P
Q
F
F
H
D
Dog
Lupus familis
XP_849774
1976
214088
S457
P
G
S
L
P
I
P
S
Q
P
E
F
S
H
D
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001082071
2104
231430
T500
A
E
D
E
N
R
A
T
Q
I
E
E
D
V
G
Zebra Danio
Brachydanio rerio
NP_001073639
1709
184731
V252
G
T
K
A
D
S
S
V
S
E
H
L
P
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798355
2169
238737
M472
K
K
S
A
E
M
K
M
Q
C
D
D
R
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.2
89.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
36.9
34.4
N.A.
N.A.
N.A.
N.A.
20.5
Protein Similarity:
100
99.5
98.2
93.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
54.5
51.3
N.A.
N.A.
N.A.
N.A.
37.6
P-Site Identity:
100
100
86.6
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
86.6
100
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
20
0
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
29
0
0
15
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% C
% Asp:
0
0
15
0
15
0
0
0
0
0
15
15
15
0
58
% D
% Glu:
0
15
0
15
15
0
0
0
0
15
29
15
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
58
15
0
0
% F
% Gly:
15
58
0
0
0
0
0
0
0
0
0
0
0
0
15
% G
% His:
0
0
0
0
0
0
0
0
0
0
15
0
0
58
0
% H
% Ile:
0
0
0
0
0
58
0
0
0
15
0
0
0
0
0
% I
% Lys:
15
15
15
0
0
0
15
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
58
0
0
0
0
0
0
0
15
0
0
0
% L
% Met:
0
0
0
0
0
15
0
15
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
43
0
0
0
58
0
58
0
0
58
0
0
15
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
86
0
43
0
0
0
0
% Q
% Arg:
0
0
0
0
0
15
0
0
0
0
0
0
15
0
15
% R
% Ser:
15
0
72
0
0
15
15
58
15
0
0
0
43
0
15
% S
% Thr:
0
15
0
0
0
0
0
15
0
0
0
0
0
29
0
% T
% Val:
0
0
0
0
0
0
0
15
0
0
0
0
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _